Comparison of Levonorgestrel-Releasing Intrauterine System, Medroxyprogesterone and Norethisterone for Treatment of Endometrial Hyperplasia without Atypia: A Randomized Clinical Trial
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چکیده
Methods: This randomized clinical study included 150 perimenopausal women with endometrial hyperplasia (EH) without atypia who were randomly assigned into three groups; 50 patients received 15 mg Medroxyprogesterone acetate (MPA), 50 patients received 15 mg Norethisterone acetate (NETA) and 50 patients in whom levonorgestrel-releasing intrauterine system (LNG-IUS) was inserted. Endometrial sampling was repeated after 6 months of therapy. Primary outcome was regression of EH while secondary outcomes included side effects, patient acceptability and cost of treatment over six months.
منابع مشابه
Levonorgestrel-releasing intrauterine system (Mirena) in compare to medroxyprogesterone acetate as a therapy for endometrial hyperplasia
BACKGROUND This study was designed to evaluate the comparison of insertion of levonorgestrel (LNG)-releasing intrauterine system versus oral medroxyprogesterone acetate on endometrial hyperplasia in a randomized controlled trial. MATERIALS AND METHODS A total of 60 women with the initial histopathological diagnosis of endometrial hyperplasia in two groups received LNG or medroxyprogesterone (...
متن کاملP-157: A Comparison of The Effect of Levonorgestrel IUD with Oral Medroxyprogesterone Acetate on Abnormal Uterine Bleeding with Simple Endometrial Hyperplasia and Fertility Preservation
Background: Endometrial hyperplasia is important clinically, because it can lead to abnormal uterine bleeding (AUB) which itself can precede to endometrial cancer. Endometrial carcinoma is the most common malignancy of the female genital tract, occurring about 75-85% in younger, perimenopousal women as hyperplasic endometrial. The treatment is hysterectomy or hormone therapy with progesterone. ...
متن کاملLNG-IUS treatment of non-atypical endometrial hyperplasia in perimenopausal women: a randomized controlled trial
OBJECTIVE To compare the efficacy of the levonorgestrel-releasing intrauterine system (LNG-IUS) and oral norethisterone acetate (NET) for treatment of non-atypical endometrial hyperplasia in perimenopausal women. METHODS One hundred and twenty perimenopausal women with non-atypical endometrial hyperplasia were selected in this randomized controlled trial. Patients received LNG-IUS (n=59) or N...
متن کاملThe effectiveness of levonorgestrel releasing intrauterine system in the treatment of endometrial hyperplasia in Korean women.
OBJECTIVE Levonorgestrel releasing intrauterine system (LNG-IUS) has been shown to treat patients with non-atypical & atypical endometrial hyperplasia (EH) successfully in many western studies. Our purpose was to examine the effectiveness of LNG-IUS in the treatment of Korean women with EH. METHODS We conducted a prospective observational study of 12 women diagnosed with EH and treated with L...
متن کاملLong-term effects of levonorgestrel-releasing intrauterine system on tamoxifen-treated breast cancer patients: a meta-analysis.
OBJECTIVE The aim of the study is to assess the efficacy of the levonorgestrel-releasing intrauterine system (LNG-IUS) on the tamoxifen-induced endometrial lesions in breast cancer patients. METHODS PubMed and EMBASE databases were searched for eligible studies. Odds ratios were obtained to estimate the association between the LNG-IUS and tamoxifen-induced endometrial lesions. The fixed effec...
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